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Comprehensive profiling of functional attributes, virulence potential and evolutionary dynamics in mycobacterial secretomes

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A Correction to this article was published on 04 January 2021

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Abstract

Mycobacterium is an interesting genus which not only includes intimidating pathogens, associated with severe devastations globally, but also comprises of non-pathogenic eco-friendly members that detoxify environmental pollutants. Secretory proteins of the mycobacterial communities are essential components which are firmly believed to facilitate proper cross-talk and apt communication with host cellular surroundings and environmental niche. Secretory elements also play vital roles in mycobacterial pathogenesis. In the present endeavor, an extensive profiling of mycobacterial secretomes, considering both pathogenic and non-pathogenic members, has been executed. Thorough analysis on amino acid composition and functional behavior of the mycobacterial secretory proteins has also been performed. In-depth scrutiny of biosynthetic cost of the secretory proteins with respect to the non-secretory ones indicated that the genus Mycobacterium strictly follows the policy of cost-minimization among the sets of imperative secretory proteins. Comprehensive assessment of potential virulence among the key secretory components signified that the pathogenic mycobacterial members possess a larger share of potentially virulent secretory elements in comparison to their non-pathogenic counterparts. Present analysis also revealed contrasted evolutionary features of the secretomes wherein secretory proteins were found to evolve faster than non-secretory proteins in mycobacterial pathogens but not in the concerned non-pathogens. Outcomes of present investigation promise to provide novel insights into the enigma of mycobacterial pathogenesis, bioremediation and adaptation in diverse niche and aid further scientific investigations associated with concerned research area.

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Change history

  • 04 January 2021

    Unfortunately, in the published paper entitled "Comprehensive profiling of functional attributes, virulence potential and evolutionary dynamics in mycobacterial secretomes" authored by Ayan Roy, Arnab Sen, Sourav Chakraborty and Indrani Sarkar, the surname of Sourav Chakraborty was inadvertently wrongly written as Sourav Chakrobarty in the original publication of the article. Name has been corrected in the correction article. We have also included ORCID ID.

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Acknowledgements

The authors acknowledge the Department of Biotechnology, Government of India, for providing financial assistance in setting up of Bioinformatics Infrastructural Facility (BIF) at University of North Bengal. AS acknowledges the grant received from Department of Biotechnology, Govt. of West Bengal (Project No. 206/BT-Estt./RD-22/2014). AR acknowledges CSIR for providing financial assistance during execution of the work. IS acknowledges the receipt of UGS-BSR fellowship.

Funding

The funding was provided by Department of Biotechnology, Government of India, Department of Biotechnology, Government of West Bengal, India (Project No. 206/BT-Estt./RD-22/2014), Council of Scientific and Industrial Research and University Grants Commission.

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  1. Bioinformatics Facility, Department of Botany, University of North Bengal, Siliguri, 734013, India

    Ayan Roy, Arnab Sen, Sourav Chakraborty & Indrani Sarkar

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  1. Ayan Roy
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  2. Arnab Sen
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Correspondence to Indrani Sarkar.

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The Original online version of this article was revised: Author name “Sourav Chakraborty” has been corrected.

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Roy, A., Sen, A., Chakraborty, S. et al. Comprehensive profiling of functional attributes, virulence potential and evolutionary dynamics in mycobacterial secretomes. World J Microbiol Biotechnol 34, 5 (2018). https://doi.org/10.1007/s11274-017-2388-1

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